Molecular Mechanisms of Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia: Ongoing Challenges and Future Treatments

Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive acute myeloid leukemia (AML) remains a challenge despite the development of novel FLT3-directed tyrosine kinase inhibitors (TKI); the relapse rate is still high even after allogeneic stem cell transplantation....

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Bibliographic Details

Published in:	Cells
Main Authors:	Sebastian Scholl, Maximilian Fleischmann, Ulf Schnetzke, Florian H. Heidel
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	acute myeloid leukemia AML FMS-like tyrosine kinase 3 FLT3 FLT3-ITD FLT3-TKD
Online Access:	https://www.mdpi.com/2073-4409/9/11/2493