Knock-out of CD73 delays the onset of HR-negative breast cancer by reprogramming lipid metabolism and is associated with increased tumor mutational burden

Objective: CD73 (ecto-5′-nucleotidase, NT5E), a cell-surface enzyme converting 5′-AMP to adenosine, is crucial for cancer progression. However, its role in the tumorigenesis process remains mostly obscure. We aimed to demonstrate CD73's role in breast cancer (BC) tumorigenesis through metabolic...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Paweł Kamil Serafin, Marta Popęda, Kamila Bulak, Agata Zwara, Barbara Galikowska-Bogut, Anna Przychodzka, Adriana Mika, Tomasz Śledziński, Marcin Stanisławowski, Kamila Jendernalik, Marika Bolcewicz, Wiktoria Laprus, Grzegorz Stasiłojć, Rafał Sądej, Anna Żaczek, Leszek Kalinowski, Patrycja Koszałka
Format:	Article
Language:	English
Published:	Elsevier 2024-11-01
Subjects:	CD73 Breast cancer tumorigenesis Progesterone receptor Lipid metabolism PPARγ Tumor mutational burden
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877824001662