SARS-CoV-2 Nsp1 Is a Major Suppressor of HLA Class I and Class II Expression

Human leukocyte antigen class I (HLA-I) molecules present intracellular peptides on the cell surface to enable CD8+ T cells to effectively control viral infections. Many viruses disrupt this antigen presentation pathway to evade immune detection. In this study, we demonstrate that SARS-CoV-2 Nsp1 im...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Ivo Schirmeister, Nicolas Eckert, Sebastian Weigang, Jonas Fuchs, Lisa Kern, Georg Kochs, Anne Halenius
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	MHC ORF8 Nsp1
Online Access:	https://www.mdpi.com/1999-4915/17/8/1083