Evaluating the immunogenicity of a mouse partial hindlimb for composite allotransplantation

BackgroundVascularized composite allotransplantation (VCA) offers a promising solution for restoring function in patients with severe tissue trauma, yet acute rejection remains a major hurdle. Acute rejection is driven by an immune response against transplanted tissues, requiring lifelong immunosupp...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Jia Hui (Angela) Sun, Samantha Ligi, Felor Biniazan, Siba Haykal
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	vascularized composite allotransplantation immunogenicity graft rejection tolerance induction tissue engineering
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1595319/full