Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues

Aging: Slowing down of nucleocytoplasmic trafficking Proteins that move genetic information out of the nucleus and into the rest of the cell may be important in aging, and serve as markers of early-stage cancer. DNA is stored in the cell’s nucleus, and the messages which it encodes must be exported...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Experimental and Molecular Medicine
المؤلفون الرئيسيون: Sung Young Kim, Eun Jae Yang, Sung Bae Lee, Young-Sam Lee, Kyoung A. Cho, Sang Chul Park
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Nature Publishing Group 2020-08-01
الوصول للمادة أونلاين:https://doi.org/10.1038/s12276-020-00490-x