First reported advanced pancreatic cancer with hyperprogression treated with PD-1 blockade combined with chemotherapy: a case report and literature review

Abstract Pancreatic cancer is among the most immune-resistant tumor types due to its unique tumor microenvironment and low cancer immunogenicity. Single-agent immune modulators have thus far proven clinically ineffective. However, a growing body of evidence suggests that combination of these modulat...

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Bibliographic Details

Published in:	Discover Oncology
Main Authors:	Ya-Zhou Wang, Mao-Zhen Peng, Yao-Lin Xu, Ying Ying, Lin-Hui Tang, Hua-Xiang Xu, Jun-Yi He, Liang Liu, Wen-Quan Wang
Format:	Article
Language:	English
Published:	Springer 2024-10-01
Subjects:	Pancreatic cancer Combination therapy MDM4 amplification Hyperprogressive disease Case report
Online Access:	https://doi.org/10.1007/s12672-024-01420-3