Mouse pancreatic tumor organoids reveal synergistic efficacy of low-dose anticancer drug and radiation combinations

BackgroundPancreatic cancer is the fourth-leading cause of cancer death in the United States, with a 5-year survival rate of only 13%. Most patients with locally advanced pancreatic cancer receive chemotherapy with or without radiation therapy (RT). However, current treatment approaches often result...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Zachery Keepers, Aniketh Sharma, Sanjit Roy, Hurley Ryan, Binny Bhandary, Lei Ren, Narottam Lamichhane, Hem D. Shukla
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	pancreatic cancer radiation therapy organoid combination therapy 5-fluorouracil (5-FU) gemcitabine
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1661521/full