X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Abstract: The zymogen protease plasminogen and its active form plasmin perform key roles in blood clot dissolution, tissue remodeling, cell migration, and bacterial pathogenesis. Dysregulation of the plasminogen/plasmin system results in life-threatening hemorrhagic disorders or thrombotic vascular...

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Bibliographic Details

Published in:	Blood Advances
Main Authors:	Ruby H.P. Law, Guojie Wu, Eleanor W.W. Leung, Koushi Hidaka, Adam J. Quek, Tom T. Caradoc-Davies, Devadharshini Jeevarajah, Paul J. Conroy, Nigel M. Kirby, Raymond S. Norton, Yuko Tsuda, James C. Whisstock
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952920301853