Mice with humanized immune system as novel models to study HIV-associated pulmonary hypertension

People living with HIV and who receive antiretroviral therapy have a significantly improved lifespan, compared to the early days without therapy. Unfortunately, persisting viral replication in the lungs sustains chronic inflammation, which may cause pulmonary vascular dysfunction and ultimate life-t...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Valerie J. Rodriguez-Irizarry, Alina C. Schneider, Daniel Ahle, Justin M. Smith, Edu B. Suarez-Martinez, Ethan A. Salazar, Brianyell McDaniel Mims, Fahmida Rasha, Hanna Moussa, Naima Moustaïd-Moussa, Kevin Pruitt, Marcelo Fonseca, Mauricio Henriquez, Matthias A. Clauss, Matthew B. Grisham, Sharilyn Almodovar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	HIV HIV-associated pulmonary hypertension HIV-PH HIV-PH Pulmonary hypertension EMAP II hypoxia
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.936164/full