Innate immune dysfunction and persistent activation in South African HIV elite controllers

BackgroundElite controllers can spontaneously control HIV-1 infection without antiretroviral treatment but remain at risk of developing non-AIDS-related conditions. The adaptive immune system is key in mediating spontaneous viral control; however, the innate immune response remains understudied. We...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Asisipo Mohamed, Yenzekile Zungu, Sharon Shalekoff, Osman Ebrahim, Ziyaad Waja, Neil Martinson, Caroline T. Tiemessen, Christina Thobakgale
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Subjects:
HIV-1
HIV elite controllers
antigen-presenting cells
monocyte activation
proinflammatory cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603436/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603436/full

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