ICOR: improving codon optimization with recurrent neural networks

Abstract Background In protein sequences—as there are 61 sense codons but only 20 standard amino acids—most amino acids are encoded by more than one codon. Although such synonymous codons do not alter the encoded amino acid sequence, their selection can dramatically affect the expression of the resu...

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Bibliographic Details

Published in:	BMC Bioinformatics
Main Authors:	Rishab Jain, Aditya Jain, Elizabeth Mauro, Kevin LeShane, Douglas Densmore
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Codon optimization Genetic design Synthetic biology Machine learning
Online Access:	https://doi.org/10.1186/s12859-023-05246-8