Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models

Trans-differentiation of hepatic stellate cells (HSCs) to activated state potentiates liver fibrosis through release of extracellular matrix (ECM) components, distorting the liver architecture. Since limited antifibrotics are available, pharmacological intervention targeting activated HSCs may be co...

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Bibliographic Details

Published in:	eLife
Main Authors:	Komal Ramani, Nirmala Mavila, Aushinie Abeynayake, Maria Lauda Tomasi, Jiaohong Wang, Michitaka Matsuda, Eki Seki
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2022-10-01
Subjects:	A-kinase anchor protein liver fibrosis phosphorylation scaffolding protein
Online Access:	https://elifesciences.org/articles/78430