Regulators, functions, and mechanotransduction pathways of matrix stiffness in hepatic disease

The extracellular matrix (ECM) provides physical support and imparts significant biochemical and mechanical cues to cells. Matrix stiffening is a hallmark of liver fibrosis and is associated with many hepatic diseases, especially liver cirrhosis and carcinoma. Increased matrix stiffness is not only...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Ting Guo, Cindy Wantono, Yuyong Tan, Feihong Deng, Tianying Duan, Deliang Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	liver fibrosis extracellular matrix matrix stiffness mechanotransduction mechanotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2023.1098129/full