Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One subtype, SCA14, is caused by mutations of Protein Kinase C gamma (PKCγ), the dominant PKC isoform present in Purkinje ce...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Molecular Neuroscience
المؤلفون الرئيسيون: Josef P. Kapfhammer, Etsuko Shimobayashi
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2023-06-01
الموضوعات:
cerebellum
neurodegenerative diseases
spinocerebellar ataxia (SCA)
Purkinje cell
Protein Kinase C gamma
الوصول للمادة أونلاين:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1182431/full

الانترنت

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1182431/full

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