Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One subtype, SCA14, is caused by mutations of Protein Kinase C gamma (PKCγ), the dominant PKC isoform present in Purkinje ce...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Josef P. Kapfhammer, Etsuko Shimobayashi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	cerebellum neurodegenerative diseases spinocerebellar ataxia (SCA) Purkinje cell Protein Kinase C gamma
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1182431/full