Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One subtype, SCA14, is caused by mutations of Protein Kinase C gamma (PKCγ), the dominant PKC isoform present in Purkinje ce...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Frontiers in Molecular Neuroscience
المؤلفون الرئيسيون: Josef P. Kapfhammer, Etsuko Shimobayashi
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Frontiers Media S.A. 2023-06-01
الموضوعات:
الوصول للمادة أونلاين:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1182431/full