Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One subtype, SCA14, is caused by mutations of Protein Kinase C gamma (PKCγ), the dominant PKC isoform present in Purkinje ce...

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書誌詳細

出版年:	Frontiers in Molecular Neuroscience
主要な著者:	Josef P. Kapfhammer, Etsuko Shimobayashi
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2023-06-01
主題:	cerebellum neurodegenerative diseases spinocerebellar ataxia (SCA) Purkinje cell Protein Kinase C gamma
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1182431/full