Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

Abstract The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4). Here, we determine cryoEM maps of full-length...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Susan A. Leonhardt, Michael D. Purdy, Jonathan R. Grover, Ziwei Yang, Sandra Poulos, William E. McIntire, Elizabeth A. Tatham, Satchal K. Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D. Uchil, Andrés Finzi, Alan Rein, Anthony A. Kossiakoff, Walther Mothes, Mark Yeager
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Online Access:	https://doi.org/10.1038/s41467-023-39262-2