Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection

It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x viru...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Min-Chul Kim, Ki-Hye Kim, Jeong Woo Lee, Yu-Na Lee, Hyo-Jick Choi, Yu-Jin Jung, Yu-Jin Kim, Richard W. Compans, Mark R. Prausnitz, Sang-Moo Kang
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Subjects:	microneedle patch delivery skin cross protection M2e supplemented vaccines
Online Access:	https://www.mdpi.com/1999-4923/11/4/188