Lower affinity T cells are critical components and active participants of the immune response

Kinetic and biophysical parameters of T cell receptor (TCR) and peptide:MHC (pMHC) interaction define intrinsic factors required for T cell activation and differentiation. Although receptor ligand kinetics are somewhat cumbersome to assess experimentally, TCR:pMHC affinity has been shown to predict...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Ryan eMartinez, Brian eEvavold
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-09-01
Subjects:	T cells Tetramers 2D assays TCR Affinity T cell diversity
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00468/full