Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis

Abstract Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1). Neuroinflammation in multiple sclerosis (MS) is li...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Mark Walkenhorst, Jana K. Sonner, Nina Meurs, Jan Broder Engler, Simone Bauer, Ingo Winschel, Marcel S. Woo, Lukas Raich, Iris Winkler, Vanessa Vieira, Lisa Unger, Gabriela Salinas, Olivier Lantz, Manuel A. Friese, Anne Willing
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-10-01
Online Access:	https://doi.org/10.1038/s41467-024-53657-9