Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1

The optimization of the affinity of monoclonal antibodies is crucial for the development of drug candidates, as it can impact the efficacy of the drug and, thus, the dose and dosing regimen, limit adverse effects, and reduce therapy costs. Here, we present the affinity maturation of an EGFR×PD-L1 Tw...

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Bibliographic Details

Published in:	Antibodies
Main Authors:	Julia Harwardt, Felix Klaus Geyer, Katrin Schoenfeld, David Baumstark, Vera Molkenthin, Harald Kolmar
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	antibody affinity maturation bispecific antibody Two-in-One antibody yeast display EGFR binding PD-L1 binding
Online Access:	https://www.mdpi.com/2073-4468/13/2/36