Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides

Synthetic cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) are promising candidates for vaccine adjuvants, because they activate immune responses through the Toll-like receptor 9 (TLR9) pathway. However, unmodified CpG ODNs are quickly degraded by serum nucleases, and their negative charg...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Soumitra Pathak, Nguyen Bui Thao Le, Taiji Oyama, Yusuke Odahara, Atsuya Momotake, Kazunori Ikebukuro, Chiho Kataoka-Hamai, Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Subjects:	CpG oligodeoxynucleotides adjuvants guanine-quadruplex immune response toll like receptor 9 macrophage cells
Online Access:	https://www.mdpi.com/2218-273X/15/1/95