Phasing millions of samples achieves near perfect accuracy, enabling parent-of-origin analyses

Summary: Haplotype phasing, the process of determining which genetic variants are physically located on the same chromosome, is crucial for genetic analyses. Here, we benchmark SHAPEIT and Beagle, two state-of-the-art phasing methods, on two large datasets: >8 million research-consented 23andMe,...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	HGG Advances
المؤلفون الرئيسيون:	Cole M. Williams, Jared O’Connell, Ethan Jewett, William A. Freyman, Christopher R. Gignoux, Sohini Ramachandran, Amy L. Williams
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2025-10-01
الموضوعات:	haplotype phasing identity-by-descent population genetics statistical phasing parent-of-origin inheritance
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S266624772500082X