Cross‐tissue multi‐omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism

Abstract The gut microbiota influences host immunity and metabolism, and changes in its composition and function have been implicated in several non‐communicable diseases. Here, comparing germ‐free (GF) and specific pathogen‐free (SPF) mice using spatial transcriptomics, single‐cell RNA sequencing,...

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Bibliographic Details

Published in:	iMeta
Main Authors:	Juan Shen, Weiming Liang, Ruizhen Zhao, Yang Chen, Yanmin Liu, Wei Cheng, Tailiang Chai, Yin Zhang, Silian Chen, Jiazhe Liu, Xueting Chen, Yusheng Deng, Zhao Zhang, Yufen Huang, Huanjie Yang, Li Pang, Qinwei Qiu, Haohao Deng, Shanshan Pan, Linying Wang, Jingjing Ye, Wen Luo, Xuanting Jiang, Xiao Huang, Wanshun Li, Elaine Lai‐Han Leung, Lu Zhang, Li Huang, Zhimin Yang, Rouxi Chen, Junpu Mei, Zhen Yue, Hong Wei, Kristiansen Karsten, Lijuan Han, Xiaodong Fang
Format:	Article
Language:	English
Published:	Wiley 2025-02-01
Subjects:	aggregation index bile acid and lipid metabolism germ‐free mice immune homeostasis lipid droplet spatial transcriptomics and single‐cell RNA sequencing
Online Access:	https://doi.org/10.1002/imt2.272