Deciphering conformational dynamics in AFM data using fast nonlinear NMA and FFT-based search with AFMFit

Abstract Atomic Force Microscopy (AFM) offers a unique opportunity to study the conformational dynamics of proteins in near-physiological conditions at the single-molecule level. However, interpreting the two-dimensional molecular surfaces of multiple molecules measured in AFM experiments as three-d...

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Bibliographic Details
Published in:Communications Biology
Main Authors: Rémi Vuillemot, Jean-Luc Pellequer, Sergei Grudinin
Format: Article
Language:English
Published: Nature Portfolio 2025-09-01
Online Access:https://doi.org/10.1038/s42003-025-08365-5