Unaltered Liver Regeneration in Post-Cholestatic Rats Treated with the FXR Agonist Obeticholic Acid

In a previous study, obeticholic acid (OCA) increased liver growth before partial hepatectomy (PHx) in rats through the bile acid receptor farnesoid X-receptor (FXR). In that model, OCA was administered during obstructive cholestasis. However, patients normally undergo PHx several days after biliary...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Lianne R. de Haan, Joanne Verheij, Rowan F. van Golen, Verena Horneffer-van der Sluis, Matthew R. Lewis, Ulrich H. W. Beuers, Thomas M. van Gulik, Steven W. M. Olde Damink, Frank G. Schaap, Michal Heger, Pim B. Olthof
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Subjects:	bile duct obstruction pharmacological intervention bile salts liver regeneration partial hepatectomy biliary obstruction
Online Access:	https://www.mdpi.com/2218-273X/11/2/260