Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

Hyaluronan and proteoglycan link protein 1 (Hapln1) supports active cardiomyogenesis in zebrafish hearts, but its regulation in mammal cardiomyocytes is unclear. This study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therap...

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Bibliographic Details

Published in:	Journal of Pharmaceutical Analysis
Main Authors:	Ding-Jun Hao, Yue Qin, Shi-Jie Zhou, Bu-Huai Dong, Jun-Song Yang, Peng Zou, Li-Ping Wang, Yuan-Ting Zhao
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	Hapln1 Versican GDF11 iPSC-CMs Cardiomyocyte proliferation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177923002514