Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors

Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway. Constitutive activation is achieved through multiple mechanisms, including activating mutations in NFE2L2 (NRF2). To determine the functional...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	John G. Witherspoon, Jonathan R. Hall, Dereje Jima, Hannah M. Atkins, Nathan T. Wamsley, Michael B. Major, Bernard E. Weissman, Robert C. Smart
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Nrf2 NFE2L2 KEAP1 Mouse skin multistage carcinogenesis model Ras Papilloma
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231724002398