MiR-340-5p regulates PD-L1 and predicts pembrolizumab response in extranodal NK/T-cell lymphoma

Abstract Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive, chemoresistant non-Hodgkin lymphoma subtype with poor patient outcomes linked to elevated PD-L1 expression. This study investigates miRNA-mediated regulation of PD-L1, focusing on miR-340-5p and miR-424-5p as novel therapeutic targets...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Kyung Ju Ryu, Haein Ji, Bon Park, Sang Eun Yoon, Junhun Cho, Won Seog Kim, Hyeon Ho Kim, Seok Jin Kim
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Subjects:	PD-L1 miR-340-5p NK/T-cell Lymphoma Biomarkers
Online Access:	https://doi.org/10.1038/s41598-025-90542-x