CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder

Abstract T-cell therapies based on chimeric antigen receptor (CAR) targeting of a tumor-specific antigen offer hope for patients with relapsed or refractory cancers. CAR hinge and transmembrane regions link antigen recognition domains to intracellular signal transduction domains. Here, we apply biop...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Varvara Folimonova, Xiang Chen, Hitendra Negi, Charles D. Schwieters, Jess Li, R. Andrew Byrd, Naomi Taylor, Philippe Youkharibache, Kylie J. Walters
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-08-01
Online Access:	https://doi.org/10.1038/s42003-024-06770-w