Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents

We recently reported that bacteria can be found within pancreatic ductal adenocarcinoma (PDAC) tumors. Some of these bacteria can metabolize and thereby inactivate the nucleoside analog gemcitabine. We demonstrated that the long isoform of the bacterial enzyme cytidine deaminase (CDD) mediates the m...

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Bibliographic Details

Published in:	Molecular & Cellular Oncology
Main Authors:	Leore T. Geller, Ravid Straussman
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Subjects:	chemoresistance drug metabolism gemcitabine mycoplasma novel therapeutic targets pancreatic ductal adenocarcinoma pdac mechanisms of resistance to therapy tumor microbiome
Online Access:	http://dx.doi.org/10.1080/23723556.2017.1405139