Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes

The Epstein–Barr virus (EBV)-encoded oncoprotein latent membrane protein 1 (LMP1) constitutively activates nuclear factor κB (NFκB) from intracellular membranes to promote cell growth and survival. LMP1 associates with CD63 in intracellular membranes and is released via exosomes. Whether tumour necr...

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Bibliographic Details

Published in:	Journal of Extracellular Vesicles
Main Authors:	Frederik J. Verweij, Cecilia de Heus, Stefanie Kroeze, Houjian Cai, Elliott Kieff, Sander R. Piersma, Connie R. Jimenez, Jaap M. Middeldorp, Dirk Michiel Pegtel
Format:	Article
Language:	English
Published:	Wiley 2015-04-01
Subjects:	LMP1 oncogenic signalling endosomes exosomes palmitoylation
Online Access:	http://www.journalofextracellularvesicles.net/index.php/jev/article/view/26334/pdf_15