Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons

Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging process. Recent evidence indicates that prion-like propagation of misfolded α...

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Bibliographic Details

Published in:	Molecular Brain
Main Authors:	Tae-Young Ha, Yu Ree Choi, Hye Rin Noh, Seon-Heui Cha, Jae-Bong Kim, Sang Myun Park
Format:	Article
Language:	English
Published:	BMC 2021-07-01
Subjects:	Parkinson’s disease α-synuclein Cell-to-cell transmission Endocytosis Caveolin-1 Aging
Online Access:	https://doi.org/10.1186/s13041-021-00834-2