Multifaceted Analyses of Isolated Mitochondria Establish the Anticancer Drug 2-Hydroxyoleic Acid as an Inhibitor of Substrate Oxidation and an Activator of Complex IV-Dependent State 3 Respiration

The synthetic fatty acid 2-hydroxyoleic acid (2OHOA) has been extensively investigated as a cancer therapy mainly based on its regulation of membrane lipid composition and structure, activating various cell fate pathways. We discovered, additionally, that 2OHOA can uncouple oxidative phosphorylation...

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Bibliographic Details

Published in:	Cells
Main Authors:	Kumudesh Mishra, Mária Péter, Anna Maria Nardiello, Guy Keller, Victoria Llado, Paula Fernandez-Garcia, Ulf D. Kahlert, Dinorah Barasch, Ann Saada, Zsolt Török, Gábor Balogh, Pablo V. Escriba, Stefano Piotto, Or Kakhlon
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Subjects:	2-hydroxyoleic acid mitochondria molecular dynamics respiration glycolysis shotgun lipidomics
Online Access:	https://www.mdpi.com/2073-4409/11/3/578