ROBO1 p.E280* Loses the Inhibitory Effects on the Proliferation and Angiogenesis of Wild-Type ROBO1 in Cholangiocarcinoma by Interrupting SLIT2 Signal

BackgroundCholangiocarcinoma (CCA) remains one of the most lethal malignancies with an increasing incidence globally. Through whole-exome sequencing of 67 CCA tissues, we identified new mutated genes in CCA, including MACF1, METTL14, ROBO1, and so on. The study was designed to explore the effects an...

Full description

Bibliographic Details
Published in:Frontiers in Oncology
Main Authors: Tao Zhou, Yaodong Zhang, Yananlan Chen, Jijun Shan, Jifei Wang, Yirui Wang, Jiang Chang, Wangjie Jiang, Ruixiang Chen, Ziyi Wang, Xiaoli Shi, Yue Yu, Changxian Li, Xiangcheng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Subjects:
cholangiocarcinoma
ROBO1
nonsense mutation
proliferation
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.879963/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.879963/full

Similar Items