Sex-Specific ADHD-like Behaviour, Altered Metabolic Functions, and Altered EEG Activity in Sialyltransferase ST3GAL5-Deficient Mice

A deficiency in GM3-derived gangliosides, resulting from a lack of lactosylceramide-alpha-2,3-sialyltransferase (ST3GAL5), leads to severe neuropathology, including epilepsy and metabolic abnormalities. Disruption of ganglioside production by this enzyme may also have a role in the development of ne...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Tatyana Strekalova, Ekaterina Veniaminova, Evgeniy Svirin, Ekaterina Kopeikina, Tatyana Veremeyko, Amanda W. Y. Yung, Andrey Proshin, Shawn Zheng Kai Tan, Sharafuddin Khairuddin, Lee Wei Lim, Klaus-Peter Lesch, Susanne Walitza, Daniel C. Anthony, Eugene D. Ponomarev
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) attention-deficit/hyperactivity disorder (ADHD) insulin receptor (IR) sex differences electroencephalogram (EEG) mice
Online Access:	https://www.mdpi.com/2218-273X/11/12/1759