TGF<i>β</i> Inhibitor A83-01 Enhances Murine HSPC Expansion for Gene Therapy

Murine hematopoietic stem and progenitor cells (HSPCs) are commonly used as model systems during gene therapeutic retroviral vector development and preclinical biosafety assessment. Here, we developed cell culture conditions to maintain stemness and prevent differentiation during HSPC culture. We us...

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Bibliographic Details

Published in:	Cells
Main Authors:	Jenni Fleischauer, Antonella Lucia Bastone, Anton Selich, Philipp John-Neek, Luisa Weisskoeppel, Dirk Schaudien, Axel Schambach, Michael Rothe
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	hematopoietic stem and progenitor cells stem cell expansion A83-01 TGFbeta signaling mast cells gene therapy
Online Access:	https://www.mdpi.com/2073-4409/12/15/1978