Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

Dysregulated PI3K/Akt signaling occurs commonly in breast cancers and is due to HER2 amplification, PI3K mutation or PTEN inactivation. The objective of this study was to determine the role of Akt activation in breast cancer as a function of mechanism of activation and whether inhibition of Akt sign...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Qing-Bai She, Sarat Chandarlapaty, Qing Ye, Jose Lobo, Kathleen M Haskell, Karen R Leander, Deborah DeFeo-Jones, Hans E Huber, Neal Rosen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-08-01
Online Access:	http://europepmc.org/articles/PMC2516933?pdf=render