Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

Artemisinin, isolated from the traditional Chinese medicinal plant qīng hāo 青蒿 (Artemisia annua) and its derivatives are used for treatment of malaria. With treatment failures now being recorded for the derivatives and companion drugs used in artemisinin combination therapies new drug combinations a...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Jerome P. L. Ng, Yu Han, Li Jun Yang, Lyn-Marie Birkholtz, Dina Coertzen, Ho Ning Wong, Richard K. Haynes, Paolo Coghi, Vincent Kam Wai Wong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	celastrol redox drug artemisinin artemisone synergism malaria
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.988748/full