The iNKT cell ligand α-GalCer prevents murine septic shock by inducing IL10-producing iNKT and B cells

Introductionα-galactosylceramide (α-GalCer), a prototypical agonist of invariant natural killer T (iNKT) cells, stimulates iNKT cells to produce various cytokines such as IFNγ and IL4. Moreover, repeated α-GalCer treatment can cause protective or pathogenic outcomes in various immune-mediated diseas...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yun Hoo Park, Sung Won Lee, Tae-Cheol Kim, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	α-GalCer iNKT cells sepsis B cells IL10
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1457690/full