Mistranslating the genetic code with leucine in yeast and mammalian cells

Translation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do not recognize the anticodon bases. Single nucleotide anticodon variants in their cognate tRNAs can lead t...

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Bibliographic Details

Published in:	RNA Biology
Main Authors:	Josephine Davey-Young, Farah Hasan, Rasangi Tennakoon, Peter Rozik, Henry Moore, Peter Hall, Ecaterina Cozma, Julie Genereaux, Kyle S. Hoffman, Patricia P. Chan, Todd M. Lowe, Christopher J. Brandl, Patrick O’Donoghue
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	Genetic code mistranslation neuroblastoma cells protein synthesis Transfer RNA translation fidelity
Online Access:	https://www.tandfonline.com/doi/10.1080/15476286.2024.2340297