Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617

Prostate-specific membrane antigen (PSMA) binding tracers are promising agents for the targeting of prostate tumors. To further optimize the clinically established radiopharmaceutical PSMA-617, novel PSMA ligands for prostate cancer endoradiotherapy were developed. A series of PSMA binding tracers t...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	José Carlos dos Santos, Martin Schäfer, Ulrike Bauder-Wüst, Barbro Beijer, Matthias Eder, Karin Leotta, Christian Kleist, Jan-Philip Meyer, Thomas R. Dilling, Jason S. Lewis, Clemens Kratochwil, Klaus Kopka, Uwe Haberkorn, Walter Mier
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	PSMA prostate cancer PET imaging endoradiotherapy chelator
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2022.898692/full