Adaptation to acidic conditions that mimic the tumor microenvironment, downregulates miR-193b-3p, and induces EMT via TGFβ2 in A549 cells.

The acidic tumor microenvironment plays a critical role in the malignant transformation of cancer cells. One mechanism underlying this transformation involves epithelial-mesenchymal transition (EMT). This is induced by prolonged exposure to acidic conditions. EMT is an essential process in cancer pr...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Sadayuki Higashi, Munekazu Yamakuchi, Hirohito Hashinokuchi, Kazunori Takenouchi, Akito Tabaru, Yoko Oyama, Chieko Fujisaki, Kiyonori Tanoue, Teruto Hashiguchi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0318811