Assessing the capabilities of 2D fluorescence monitoring in microtiter plates with data-driven modeling for secondary substrate limitation experiments of Hansenula polymorpha

Abstract Background Non-invasive online fluorescence monitoring in high-throughput microbioreactors is a well-established method to accelerate early-stage bioprocess development. Recently, single-wavelength fluorescence monitoring in microtiter plates was extended to measurements of highly resolved...

Full description

Bibliographic Details

Published in:	Journal of Biological Engineering
Main Authors:	Christoph Berg, Laura Herbst, Lisa Gremm, Nina Ihling, Olivier Paquet-Durand, Bernd Hitzmann, Jochen Büchs
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	2D fluorescence spectroscopy Online monitoring Multivariate data analysis High-throughput Microbioreactor Microtiter plate
Online Access:	https://doi.org/10.1186/s13036-023-00332-0