Common mitochondrial deletions in RNA-Seq: evaluation of bulk, single-cell, and spatial transcriptomic datasets

Abstract Common mitochondrial DNA (mtDNA) deletions are large structural variants in the mitochondrial genome that accumulate in metabolically active tissues with age and have been investigated in various diseases. We applied the Splice-Break2 pipeline (designed for high-throughput quantification of...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Audrey A. Omidsalar, Carmel G. McCullough, Lili Xu, Stanley Boedijono, Daniel Gerke, Michelle G. Webb, Zarko Manojlovic, Adolfo Sequeira, Mark F. Lew, Marco Santorelli, Geidy E. Serrano, Thomas G. Beach, Agenor Limon, Marquis P. Vawter, Brooke E. Hjelm
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Online Access:	https://doi.org/10.1038/s42003-024-05877-4