Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

IntroductionEpCAM (Epithelial cell adhesion molecule) is a key cancer stem cell marker involved in cancer progression, making it an important target for both diagnosis and therapy. Despite efforts using anti-EpCAM monoclonal antibodies (mAbs), their anti-tumor effects have been limited. Single-domai...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Xiaofeng Zhou, Zhifang Liu, Weixiong Zhang, Lin Dai, Tao Chen, Zexiong Lin, Hong Pan, Qi Qi, Henry Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	EpCAM antibody single-domain antibody cancer stem cells cancer therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1530268/full