Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

The melanoma-associated antigen family A (MAGEA) antigens are expressed in a wide variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for cancer immunotherapy. Here we show that a number of cancer-associated MAGEA mutants that undergo proteasome-dependent de...

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Bibliographic Details

Published in:	eLife
Main Authors:	Yiu Huen Tsang, Yumeng Wang, Kathleen Kong, Caitlin Grzeskowiak, Oksana Zagorodna, Turgut Dogruluk, Hengyu Lu, Nicole Villafane, Venkata Hemanjani Bhavana, Daniela Moreno, Sarah H Elsea, Han Liang, Gordon B Mills, Kenneth L Scott
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-04-01
Subjects:	MAGEA autophagy MAGEA6 proteasome pancreatic ductal adenocarcinoma
Online Access:	https://elifesciences.org/articles/48963