Doxifluridine promotes host longevity through bacterial metabolism.

Aging is associated with alternative splicing (AS) defects that have broad implications on aging-associated disorders. However, which drug(s) can rescue age-related AS defects and extend lifespan has not been systematically explored. We performed large-scale compound screening in C. elegans using a...

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Bibliographic Details

Published in:	PLoS Genetics
Main Authors:	Rui Wei, Yuling Peng, Yamei Luo, Xinyuan Wang, Zhenzhong Pan, Ran Zhou, Huan Yang, Zongyao Huang, Yaojia Liu, Lunzhi Dai, Yuan Wang, Yan Zhang
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-03-01
Online Access:	https://doi.org/10.1371/journal.pgen.1011648