Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease

Intervention in chronically activated microglia-mediated neuroinflammation is a novel approach to treat Alzheimer's disease (AD). The low permeability of the blood‒brain barrier (BBB) and non-selective distribution in the brain severely restrict AD drugs' disease-modifying efficacy. Here,...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Ya Wei, Xue Xia, Xiaorong Wang, Wenqin Yang, Siqin He, Lulu Wang, Yongke Chen, Yang Zhou, Feng Chen, Hanmei Li, Fu Peng, Guobo Li, Zheng Xu, Jintao Fu, Huile Gao
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Subjects:	Blood‒brain barrier penetration Microglial targeting Microglial modulation Chronic neuroinflammation Alzheimer's disease Immunotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383525000218