Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia

Abstract Background Gastric intestinal metaplasia (GIM) represents an important precancerous lesion in intestinal-type gastric cancer, triggered by persistent Helicobacter pylori (H. pylori) infection. In a previous study, we unveiled SlyD as a novel virulence factor of H. pylori, establishing its r...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	H. pylori SlyD Gastric intestinal metaplasia CDX2 Gastric precancerous disease Dihydroartemisinin
Online Access:	https://doi.org/10.1186/s12916-025-03911-8