Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV

IntroductionSubcutaneous adipose tissue (SAT) is a critical regulator of systemic metabolic homeostasis. Persons with HIV (PWH) have an increased risk of metabolic diseases and significant alterations in the SAT immune environment compared with the general population.MethodsWe generated a comprehens...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Samuel S. Bailin, Jonathan A. Kropski, Rama D. Gangula, LaToya Hannah, Joshua D. Simmons, Mona Mashayekhi, Fei Ye, Run Fan, Simon Mallal, Christian M. Warren, Spyros A. Kalams, Curtis L. Gabriel, Celestine N. Wanjalla, John R. Koethe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	human immunodeficiency virus type 2 diabetes mellitus white adipose tissue subcutaneous adipose tissue single-cell RNA sequencing immune cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152003/full