In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation

Protein-protein interaction (PPI) networks provide a static map of functional protein interactions, which when combined with algorithms, can prioritize key protein candidates which experimental studies cannot capture. This study, aimed to construct knowledge-based nucleus pulposus (NP)-specific PPI...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Low back pain Intervertebral disc degeneration PPI network Proteomics Candidate prioritisation Prioritisation algorithm
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037025001370